CARDIOVASCULAR EFFECTS OF SELECTIVE COX-2 INHIBITORS IN RHEUMATIC DISEASES
نویسندگان
چکیده
منابع مشابه
Risk of cardiovascular events associated with selective COX-2 inhibitors.
Atherosclerosis is a process with inflammatory features and selective cyclooxygenase 2 (COX-2) inhibitors may potentially have antiatherogenic effects by virtue of inhibiting inflammation. However, by decreasing vasodilatory and antiaggregatory prostacyclin production, COX-2 antagonists may lead to increased prothrombotic activity. To define the cardiovascular effects of COX-2 inhibitors when u...
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D a t a e x t r a c t i o n Data were extracted on study methods, patient characteristics, drug regimens, aspirin use, and cardiovascular events. M a i n r e s u l t s 4 studies met the selection criteria. The Vioxx Gastrointestinal Outcomes Research study compared rofecoxib, 50 mg/d, with naproxen, 1000 mg/d, in 8076 patients with rheumatoid arthritis. Aspirin use was not permitted. Patients i...
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A new series of peptide-like derivatives containing different aromatic amino acids andpossessing pharmacophores of COX-2 inhibitors as SO2Me or N3 attached to the para positionof an end phenyl ring was synthesized for evaluation as selective cyclooxygenase-2 (COX-2)inhibitors. The synthetic reactions were based on the solid phase peptide synthesis methodusing Wang resin. One of the analogues, i...
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The controversy over the cardiovascular risks of cox-2 inhibitors stems from 2 main trials: VIGOR and CLASS. These two trials were designed to assess the gastrointestinal safety of rofecoxib (Vioxx) and celecoxib (Celebrex), respectively. From these trials, it was observed that the cox-2 inhibitors had a higher number of cardiovascular events than the NSAIDS that they were paired against. For e...
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ژورنال
عنوان ژورنال: Modern Rheumatology Journal
سال: 2010
ISSN: 2310-158X,1996-7012
DOI: 10.14412/1996-7012-2010-609